Weight-Loss Drugs: Long-term medication helps woman maintain 137-pound weight after decades of obesity
After years of unsuccessful diets and bariatric surgery, a combination of medications has helped Barbara Senich sustain significant weight loss despite high treatment costs.

Barbara Senich says long-term medication has helped her maintain significant weight loss.
Weight-Loss Drugs have helped a 69-year-old woman maintain a dramatic weight loss after decades of struggling with obesity, offering what she describes as the first lasting solution in her lifelong battle with weight management.
Barbara Senich, 69, said she spent 35 years wearing only black trousers because she believed darker clothing made her appear slimmer. Standing 5 feet 11 inches tall, she reached a peak weight of 340 pounds and spent years trying to lose weight through various methods.
She successfully lost more than 100 pounds twice by following all-liquid diets, but each time the weight eventually returned. Bariatric surgery later reduced her weight to 185 pounds, but those results also proved temporary as she gradually regained weight.
Senich said she kept several sizes of clothing in her wardrobe because she expected her weight to increase again. About five years ago, however, she finally donated her larger clothes after achieving stable weight loss that has lasted.
Her weight has remained around 137 pounds with a treatment plan that combines the GLP-1 medication Zepbound, Metformin, which helps treat insulin resistance, and Contrave, a prescription medicine that helps manage binge eating and appetite.
Senich said the greatest benefit of the treatment has been maintaining her weight rather than simply losing it. She now feels comfortable wearing lighter-coloured clothing, including white and pale pink trousers, which she previously avoided.
Although the medications have delivered lasting results, they have also created a significant financial burden. Senich purchases Zepbound through LillyDirect, a programme offered by Eli Lilly and Company that lowers some costs. However, she still pays for the medication herself because her Medicare prescription drug plan does not cover medicines prescribed solely for weight loss.
Her experience reflects a broader challenge facing many patients who benefit from newer anti-obesity medications but struggle to afford long-term treatment when insurance coverage is limited.
