BY : Dr Syed Muhammad Nazim
Kidney cancer, particularly renal cell carcinoma (RCC), is not as frequently discussed as other
cancers, yet it remains a significant global health issue, with increasing prevalence and mortality
rates. Often asymptomatic in its early stages, RCC can go unnoticed, making awareness and
early detection vital for improving patient outcomes. This article highlights the importance of
kidney cancer awareness and the advanced treatment options available at the Aga Khan
University Hospital (AKUH).
The Prevalence of Kidney Cancer
Kidney cancer ranks as the 13th most common cancer globally, accounting for around 3% of all
cancer cases. In the U.S., it is among the top ten cancers, with an estimated 81,610 new cases
expected in 2024. The disease is most common in individuals aged 50-70, with men being more
frequently affected than women. The lifetime risk for men is about 2.3%, compared to 1.4% for
women. The rise in kidney cancer cases in countries like Pakistan is attributed to improved
diagnostics and lifestyle changes that elevate risk factors.
Key Risk Factors
While the exact cause of kidney cancer remains unclear, several factors are known to elevate the
risk:
Smoking: Tobacco use significantly increases the likelihood of developing RCC, with smokers being twice as likely to develop kidney cancer.
Obesity: Excess body weight is a major risk factor.
Hypertension: Chronic high blood pressure can impair kidney function and cause inflammation, raising the risk.
Genetics and Family History: A family history of kidney cancer or genetic conditions such as von Hippel-Lindau syndrome can increase susceptibility.
Occupational Exposure: Long-term exposure to industrial chemicals like cadmium and solvents can heighten the risk.
Chronic Kidney Disease & Haemodialysis: Patients with compromised kidney function or those undergoing long-term dialysis are at greater risk.
Symptoms to Watch For
Early-stage kidney cancer often lacks noticeable symptoms. As the tumour grows, however, the following signs may appear:
Blood in the urine (hematuria)
Persistent side or back pain
A lump in the flank area
Unexplained weight loss
Fatigue and loss of appetite
Low-grade fever
Since these symptoms can mimic other medical conditions, early detection is crucial for successful treatment.
Types of Kidney Cancer
There are several types of kidney cancer:
Renal Cell Carcinoma (RCC): The most common form, RCC makes up 85-90% of kidney cancer cases. It usually starts in the kidney's tubules, with the clear cell type being the most prevalent.
Transitional Cell Carcinoma: Accounting for 5-7% of kidney cancers, this type begins in the urinary system's collecting cells.
Renal Sarcoma: A rare form, making up just 1% of cases, it starts in the kidney’s connective tissues.
Wilms Tumour: A type of kidney cancer affecting children, accounting for about 5% of cases.
Diagnostic Approach
Diagnosing kidney cancer involves:
1. Medical History and Physical Examination
2. Blood Tests: Assess kidney function and overall health.
3. Urinalysis: Detects abnormal cells or blood in the urine.
4. Imaging Studies:
Ultrasound: The first imaging tool used to detect kidney abnormalities.
CT Scan: Provides detailed images to assess tumour size, location, and spread.
MRI: Offers detailed tissue analysis, especially for complex cases where CT scans are contraindicated.
Bone and PET Scans: Used when metastasis is suspected.
5. Biopsy: A tissue sample may be taken for diagnosis if cancer is suspected.
Understanding Kidney Cancer Stages
The severity of kidney cancer is determined based on tumour size, location, and whether it has spread (metastasis) to surrounding tissues or distant organs like the liver, lungs, or brain. Stage I cancer is confined to the kidney, while Stage IV involves metastasis.
Treatment Options
The choice of treatment varies based on the cancer stage and the patient’s overall health:
Surgery: The primary treatment option, including partial nephrectomy (removal of the
tumour while preserving kidney function) and radical nephrectomy (complete removal of the kidney).
Thermal Ablation: Cryoablation and radio-frequency ablation are options for patients not suited for surgery.
Targeted Therapy: Drugs that target specific cancer cells are used in advanced stages.
Immunotherapy: Boosts the body’s immune system to fight cancer cells.
Radiation Therapy: Used occasionally for symptom relief but not a primary treatment for RCC.
Active Surveillance: For slow-growing tumours, especially in elderly or medically unfit
patients.
Prevention and Risk Reduction
While kidney cancer cannot be entirely prevented, its risk can be reduced by avoiding smoking, managing high blood pressure, and maintaining a healthy weight.
AKUH’s Role in Kidney Cancer Care
The Aga Khan University Hospital offers state-of-the-art kidney cancer care, combining advanced diagnostic technologies and a multidisciplinary treatment approach:
Advanced Diagnostics: Cutting-edge imaging and lab services for precise diagnosis.
Multidisciplinary Tumour Boards: A team of experts, including urologists, oncologists, and radiologists, collaborates on personalised treatment plans.
Minimally Invasive Surgery: Laparoscopic nephrectomies and radio-frequency ablation for quicker recovery and reduced hospital stays.
Research and Support Services: AKUH is involved in ongoing research to improve kidney cancer outcomes and provides psychological support to patients.
Kidney cancer is a growing global health challenge. Awareness of its symptoms and risk factors, coupled with early detection and access to advanced treatments, can significantly improve outcomes. Institutions like the Aga Khan University Hospital are at the forefront of providing specialised care and advancing research in this critical field.
